Rosiglitazone (Avandia) and macular edema

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Rosiglitazone (Avandia) and macular edema.

The condition: Macular edema occurs when the blood vessels leak plasma into the surrounding retina. Among people with type 2 diabetes, it can be found in 15% of those who use insulin and 4% of those who do not. Risk factors for macular edema and its symptoms are listed in Box 1. Cases of rosiglitazone-related macular edema were first described in September 2005. The manufacturer of the drug, Gl...

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Introduction Over the last one decade the management of diabetic macular edema has undergone a paradigm change. This is attributed to the newer diagnostic tests and pharmacological agents. There are enough good randomized controlled trials to prove the efficacy of these drugs. However, in clinical practice, there are many situations where the application of the findings of these clinical trials...

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We review the epidemiology, pathophysiology, and etiology of cystoid macular edema (CME). Inflammatory, diabetic, post-cataract, and macular edema due to age-related macular degeneration is described. The role of chronic inflammation and hypoxia and direct macular traction is evaluated in each case according to different views from the literature. The different diagnostic methods for evaluating...

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Diabetic macular edema (DME) is arguably one of the most important challenges in ophthalmology. Macular edema refractory to laser photocoagulation remains the most prevalent cause of untreatable vision loss in diabetes and is responsible for visual disability in millions of people worldwide. The lack of an effective therapeutic solution accounts for the range of interventions proposed. These in...

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ژورنال

عنوان ژورنال: Canadian Medical Association Journal

سال: 2006

ISSN: 0820-3946,1488-2329

DOI: 10.1503/cmaj.060074